IGF-1R SIGNALING PATHWAY INHIBITORS USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES

The present invention provides compounds acting as Insulin/IGF signaling modulators useful in the treatment of neurodegenerative diseases and disorders. The invention provides pharmaceutical compositions including such compounds, and methods of using these compounds and compositions for the treatmen...

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Bibliographische Detailangaben
Hauptverfasser:	LEVITSKY, ALEXANDER, REUVENI, HADAS, COHEN, EHUD, BEN-SASSON, SHMUEL
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides compounds acting as Insulin/IGF signaling modulators useful in the treatment of neurodegenerative diseases and disorders. The invention provides pharmaceutical compositions including such compounds, and methods of using these compounds and compositions for the treatment of neurodegenerative diseases, in particular neurodegenerative diseases caused by proteotoxicity such as Alzheimer's disease. L'invention concerne des composés se comportant en modulateurs de la signalisation de l'insuline ou de la somatomédine C, c'est-à-dire du facteur de croissance 1 ressemblant à l'insuline (Insulin-like Growth Factor ou "IGF"), et convenant au traitement de maladies et troubles neurodégénératifs. L'invention propose des compositions pharmaceutiques incluant de tels composés, et des procédés d'utilisation de ces composés et compositions pour le traitement de maladies neurodégénératives, en particulier de maladies neurodégénératives provoquées, comme la maladie d'Alzheimer, par une protéotoxicité.