VACCINATION WITH RECOMBINANT MYCOBACTERIUM TUBERCULOSIS PKND ATTENUATES BACTERIAL DISSEMINATION TO THE BRAIN

Vaccines comprising Mycobacterium tuberculosis (M. tuberculosis) PknD sensor polypeptides, compositions, kits, and methods of use for treating central nervous system tuberculosis are disclosed. More specifically, the disclosure provides a method for treating or preventing central nervous system (CNS...

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Bibliographische Detailangaben
Hauptverfasser:	BE, NICHOLAS, A, JAIN, SANJAY, K, SKERRY, CIARAN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Vaccines comprising Mycobacterium tuberculosis (M. tuberculosis) PknD sensor polypeptides, compositions, kits, and methods of use for treating central nervous system tuberculosis are disclosed. More specifically, the disclosure provides a method for treating or preventing central nervous system (CNS) tuberculosis (TB) in a subject, the method comprises administering to the subject a therapeutically effective amount of a vaccine comprising an M tuberculosis PknD sensor polypeptide, or an immunogenic fragment for inhibiting or preventing M tuberculosis bacterial invasion of brain microvascular endothelia. L'invention concerne des vaccins à base de polypeptides de détection PknD de M. tuberculosis, des compositions, des kits et des méthodes d'utilisation pour traiter la tuberculose du système nerveux central.