BORDETELLA PERTUSSIS LOS-DERIVED OLIGOSACCHARIDE WITH PERTUSSIS TOXIN GLYCOCONJUGATE AND ITS APPLICATION IN THE PROPHYLAXIS AND TREATMENT OF INFECTIONS CAUSED BY BORDETELLA PERTUSSIS

The present invention relates to an immunogenic and a non-toxic glycoconjugate comprising Bordetella pertussis LOS-derived oligosaccharide and pertussis toxin, a method of preparing such glycoconjugate, the pharmaceutical composition, a vaccine composition containing such glycoconjugate, and an appl...

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Bibliographische Detailangaben
Hauptverfasser:	NIEDZIELA, TOMASZ, KOJ, SABINA, UGOWSKI, CZES AW
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to an immunogenic and a non-toxic glycoconjugate comprising Bordetella pertussis LOS-derived oligosaccharide and pertussis toxin, a method of preparing such glycoconjugate, the pharmaceutical composition, a vaccine composition containing such glycoconjugate, and an application of the glycoconjugate. The glycoconjugate is prepared as a vaccine component for protection against infections caused by Bordetella pertussis. Cette invention concerne un glycoconjugué immunogène et non toxique comprenant un oligosaccharide dérivé de Bordetella pertussis LOS et la toxine pertussique, un procédé de préparation du glycoconjugué, d'une composition pharmaceutique, d'une composition vaccinale contenant le glycoconjugué, et l'application dudit glycoconjugué. Le glycoconjugué est préparé sous la forme d'un composant vaccinal destiné à protéger contre les infections provoquées par Bordetella pertussis.