A GENETIC TEST TO PREDICT PATIENT RESPONSE TO BONE MORPHOGENETIC PROTEIN IN ARTHRODESIS

The present invention provides a method of predicting an increased likelihood of a complication associated with administration of a bone morphogenetic protein (BMP) to a subject in need of a spinal fusion surgery by detecting single nucleotide polymorphisms (SNPs) in the subject. Also provided are m...

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Bibliographische Detailangaben
Hauptverfasser:	TRENT, JEFFREY, SIETSEMA, DEBRA LYNN, JONES, CLIFFORD BARRY
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides a method of predicting an increased likelihood of a complication associated with administration of a bone morphogenetic protein (BMP) to a subject in need of a spinal fusion surgery by detecting single nucleotide polymorphisms (SNPs) in the subject. Also provided are methods of treatment with a BMP based on the presence or absence of SNPs and kits for use in detecting the SNPs. La présente invention concerne un procédé de prédiction d'une probabilité accrue d'une complication associée à l'administration d'une protéine morphogénétique osseuse (BMP) à un sujet ayant besoin d'une chirurgie de fusion spinale par la détection de polymorphismes de nucléotide unique (SNP) chez le sujet. L'invention concerne également des méthodes de traitement par un BMP sur la base de la présence ou de l'absence de SNP et des trousses pour l'utilisation dans la détection des SNP.