HISTONE DEACETYLASE INHIBITORS BASED ON DERIVATIVES OF TRICYCLIC POLYHYDROACRIDINE AND ANALOGS POSSESSING FUSED SATURATED FIVE- AND SEVEN-MEMBERED RINGS

The present invention refers to compounds of formula (I): as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or chemoprevention of cancer hematological malignancy, proliferative diseases, neurological disorders and imm...

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Hauptverfasser: OTAEGUI ANSA, DORLETA, ALDABA ARÉVALO, ENEKO, MASDEU MARGALEF, MARÍA DEL CARMEN, COSSÍO MORA, FERNANDO PEDRO, SAN SEBASTIÁN LARZABAL, EIDER, VILLAFRUELA CÁNEVA, SERGIO, VARA SALAZAR, YOSU ION, ALCALÁ CAFFARENA, MARÍA REMEDIOS, ZUBIA OLASCOAGA, AIZPEA
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:The present invention refers to compounds of formula (I): as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or chemoprevention of cancer hematological malignancy, proliferative diseases, neurological disorders and immunological disorders. La présente invention concerne des composés de formule (I) : ainsi que leur procédé de préparation, des compositions pharmaceutique les comprenant, et leur utilisation pour le traitement et/ou la chimioprévention d'une malignité hématologique cancéreuse, de maladies prolifératives, de troubles neurologiques et de troubles immunologiques.