BIOCATALYTIC PRODUCTION OF NUCLEOSIDE ANALOGUES AS ACTIVE PHARMACEUTICAL INGREDIENTS

A biocatalytic process for producing active pharmaceutical ingredients (APIs) or intermediates thereof, wherein those APIs or their intermediates are nucleoside analogues (NAs) of formula (I), and wherein said NAs are active as pharmaceutically relevant antivirals and anticancer medicaments, interme...

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Bibliographische Detailangaben
Hauptverfasser:	MONTILLA ARÉVALO, RAFAEL, PASCUAL GILABERT, MARTA, DERONCELÉ THOMAS, VICTOR MANUEL
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A biocatalytic process for producing active pharmaceutical ingredients (APIs) or intermediates thereof, wherein those APIs or their intermediates are nucleoside analogues (NAs) of formula (I), and wherein said NAs are active as pharmaceutically relevant antivirals and anticancer medicaments, intermediates or prodrugs thereof using nucleoside deoxyribosyltransferase from Lactobacillus. L'invention porte sur un procédé biocatalytique de production de principes actifs pharmaceutiques (API) ou d'intermédiaires de ces derniers. Ces API ou leurs intermédiaires sont des analogues nucléosidiques (NA) de formule (I), et lesdits NA sont actifs en tant que médicaments antiviraux et anticancéreux appropriés au plan pharmaceutique, intermédiaires ou promédicaments de ces derniers. FIG. 0: