AN IMPROVED PROCESS FOR THE PREPARATION OF FIDAXOMICIN

The present invention provides an improved process for the preparation of fidaxomicin by culturing Actinoplanes deccanensis in the culture medium of the invention wherein the fidaxomicin is produced in a yield of greater than 500mg/L broth. The present invention also provides a whole broth extractio...

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Bibliographische Detailangaben
Hauptverfasser:	PATEL, MITESH JAGDISHKUMAR, MEHTA, DHIMANT PUNJALAL, PATEL, JAYESH CHANDUBHAI, DHIMAN, ANAND MAHADEV, VAID, ANKUR SUDHIR, SHARMA, TRAUNKANT PARSHURAM
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides an improved process for the preparation of fidaxomicin by culturing Actinoplanes deccanensis in the culture medium of the invention wherein the fidaxomicin is produced in a yield of greater than 500mg/L broth. The present invention also provides a whole broth extraction process for the isolation of fidaxomicin from the fermentation broth. The present invention also provides fidaxomicin having purity of greater than 97% area by HPLC. L'invention concerne un procédé perfectionné de préparation de la fidaxomicine en cultivant Actinoplanes deccanensis dans le milieu de culture selon l'invention, la fidaxomicine étant produite à un rendement supérieur à 500 mg/l de bouillon. L'invention concerne aussi un procédé d'extraction de bouillon complet permettant d'isoler la fidaxomicine par rapport au bouillon de fermentation. L'invention concerne également une fidaxomicine ayant une pureté par HPLC supérieure à 97 % par surface.