MODULATED LYSINE VARIANT SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME

MODULATED LYSINE VARIANT SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME

The instant invention relates to modulated lysine variant species compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such modulated Lysine compositions. Methods for using such co...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: JING, YING, PEREZ THIELE, MAYDA, ZENG, XIAOBEI, KAYMAKCALAN, ZEHRA, WONG, CHEE, FURNG, SUBRAMANIAN, KARTIK
Format: Patent
Sprache:eng ; fre
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The instant invention relates to modulated lysine variant species compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such modulated Lysine compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided. La présente invention concerne des compositions d'espèces variantes de lysine modulées comprenant une protéine, par exemple un anticorps ou une partie de liaison à un antigène de celui-ci, et des procédés, par exemple des procédés de culture cellulaire et/ou purification de protéine, pour la production de telles compositions de lysine modulées. L'invention concerne également des procédés d'utilisation de telles compositions pour traiter un trouble, par exemple un trouble dans lequel TNFα est nuisible.