PROCESS FOR PREPARING PEPTIDE DEFORMYLASE INHIBITORS
The present invention relates to processes for making {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl) hydrazino]-3-oxopropyl}hydroxyformamide compounds of Formula (I), or pharmaceutically acceptable salts thereof and corresponding intermediates thereof, where such compounds are useful in the inhibition of...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | SUTTON, PETER W TABET, ELIE AMINE GRADDY, WILLIAM HAWTHORNE MCKEOWN, ROBERT RAHN BULLOCK, KAE MIYAKE MITCHELL, MARK BRYAN DESCHAMPS, NICOLE MATSUOKA, RICHARD TADAO FITZGERALD, RUSSELL SHARP, MATTHEW JUDE ELITZIN, VASSIL ZHOU, XIAOMING |
| description | The present invention relates to processes for making {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl) hydrazino]-3-oxopropyl}hydroxyformamide compounds of Formula (I), or pharmaceutically acceptable salts thereof and corresponding intermediates thereof, where such compounds are useful in the inhibition of bacterial peptide deformylase (PDF) activity and in treatment methods for bacterial infections.
Cette invention concerne des procédés de préparation de composés de {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3-oxopropyl}- hydroxyformamide de Formule (I), ou de sels pharmaceutiquement acceptables de ceux-ci et d'intermédiaires leur correspondant, lesdits composés étant utiles pour inhiber l'activité de la peptide déformylase (PDF) bactérienne et dans des méthodes destinées à traiter les infections bactériennes. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2014141181A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2014141181A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2014141181A13</originalsourceid><addsrcrecordid>eNrjZDAJCPJ3dg0OVnDzD1IICHINcAzy9HNXCHANCPF0cVVwcQWK-0b6OAa7Knj6eXg6eYb4BwXzMLCmJeYUp_JCaW4GZTfXEGcP3dSC_PjU4oLE5NS81JL4cH8jA0MTIDS0MHQ0NCZOFQCD-yiI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>PROCESS FOR PREPARING PEPTIDE DEFORMYLASE INHIBITORS</title><source>esp@cenet</source><creator>SUTTON, PETER W ; TABET, ELIE AMINE ; GRADDY, WILLIAM HAWTHORNE ; MCKEOWN, ROBERT RAHN ; BULLOCK, KAE MIYAKE ; MITCHELL, MARK BRYAN ; DESCHAMPS, NICOLE ; MATSUOKA, RICHARD TADAO ; FITZGERALD, RUSSELL ; SHARP, MATTHEW JUDE ; ELITZIN, VASSIL ; ZHOU, XIAOMING</creator><creatorcontrib>SUTTON, PETER W ; TABET, ELIE AMINE ; GRADDY, WILLIAM HAWTHORNE ; MCKEOWN, ROBERT RAHN ; BULLOCK, KAE MIYAKE ; MITCHELL, MARK BRYAN ; DESCHAMPS, NICOLE ; MATSUOKA, RICHARD TADAO ; FITZGERALD, RUSSELL ; SHARP, MATTHEW JUDE ; ELITZIN, VASSIL ; ZHOU, XIAOMING</creatorcontrib><description>The present invention relates to processes for making {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl) hydrazino]-3-oxopropyl}hydroxyformamide compounds of Formula (I), or pharmaceutically acceptable salts thereof and corresponding intermediates thereof, where such compounds are useful in the inhibition of bacterial peptide deformylase (PDF) activity and in treatment methods for bacterial infections.
Cette invention concerne des procédés de préparation de composés de {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3-oxopropyl}- hydroxyformamide de Formule (I), ou de sels pharmaceutiquement acceptables de ceux-ci et d'intermédiaires leur correspondant, lesdits composés étant utiles pour inhiber l'activité de la peptide déformylase (PDF) bactérienne et dans des méthodes destinées à traiter les infections bactériennes.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2014</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20140918&DB=EPODOC&CC=WO&NR=2014141181A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20140918&DB=EPODOC&CC=WO&NR=2014141181A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SUTTON, PETER W</creatorcontrib><creatorcontrib>TABET, ELIE AMINE</creatorcontrib><creatorcontrib>GRADDY, WILLIAM HAWTHORNE</creatorcontrib><creatorcontrib>MCKEOWN, ROBERT RAHN</creatorcontrib><creatorcontrib>BULLOCK, KAE MIYAKE</creatorcontrib><creatorcontrib>MITCHELL, MARK BRYAN</creatorcontrib><creatorcontrib>DESCHAMPS, NICOLE</creatorcontrib><creatorcontrib>MATSUOKA, RICHARD TADAO</creatorcontrib><creatorcontrib>FITZGERALD, RUSSELL</creatorcontrib><creatorcontrib>SHARP, MATTHEW JUDE</creatorcontrib><creatorcontrib>ELITZIN, VASSIL</creatorcontrib><creatorcontrib>ZHOU, XIAOMING</creatorcontrib><title>PROCESS FOR PREPARING PEPTIDE DEFORMYLASE INHIBITORS</title><description>The present invention relates to processes for making {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl) hydrazino]-3-oxopropyl}hydroxyformamide compounds of Formula (I), or pharmaceutically acceptable salts thereof and corresponding intermediates thereof, where such compounds are useful in the inhibition of bacterial peptide deformylase (PDF) activity and in treatment methods for bacterial infections.
Cette invention concerne des procédés de préparation de composés de {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3-oxopropyl}- hydroxyformamide de Formule (I), ou de sels pharmaceutiquement acceptables de ceux-ci et d'intermédiaires leur correspondant, lesdits composés étant utiles pour inhiber l'activité de la peptide déformylase (PDF) bactérienne et dans des méthodes destinées à traiter les infections bactériennes.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2014</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAJCPJ3dg0OVnDzD1IICHINcAzy9HNXCHANCPF0cVVwcQWK-0b6OAa7Knj6eXg6eYb4BwXzMLCmJeYUp_JCaW4GZTfXEGcP3dSC_PjU4oLE5NS81JL4cH8jA0MTIDS0MHQ0NCZOFQCD-yiI</recordid><startdate>20140918</startdate><enddate>20140918</enddate><creator>SUTTON, PETER W</creator><creator>TABET, ELIE AMINE</creator><creator>GRADDY, WILLIAM HAWTHORNE</creator><creator>MCKEOWN, ROBERT RAHN</creator><creator>BULLOCK, KAE MIYAKE</creator><creator>MITCHELL, MARK BRYAN</creator><creator>DESCHAMPS, NICOLE</creator><creator>MATSUOKA, RICHARD TADAO</creator><creator>FITZGERALD, RUSSELL</creator><creator>SHARP, MATTHEW JUDE</creator><creator>ELITZIN, VASSIL</creator><creator>ZHOU, XIAOMING</creator><scope>EVB</scope></search><sort><creationdate>20140918</creationdate><title>PROCESS FOR PREPARING PEPTIDE DEFORMYLASE INHIBITORS</title><author>SUTTON, PETER W ; TABET, ELIE AMINE ; GRADDY, WILLIAM HAWTHORNE ; MCKEOWN, ROBERT RAHN ; BULLOCK, KAE MIYAKE ; MITCHELL, MARK BRYAN ; DESCHAMPS, NICOLE ; MATSUOKA, RICHARD TADAO ; FITZGERALD, RUSSELL ; SHARP, MATTHEW JUDE ; ELITZIN, VASSIL ; ZHOU, XIAOMING</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2014141181A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2014</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>SUTTON, PETER W</creatorcontrib><creatorcontrib>TABET, ELIE AMINE</creatorcontrib><creatorcontrib>GRADDY, WILLIAM HAWTHORNE</creatorcontrib><creatorcontrib>MCKEOWN, ROBERT RAHN</creatorcontrib><creatorcontrib>BULLOCK, KAE MIYAKE</creatorcontrib><creatorcontrib>MITCHELL, MARK BRYAN</creatorcontrib><creatorcontrib>DESCHAMPS, NICOLE</creatorcontrib><creatorcontrib>MATSUOKA, RICHARD TADAO</creatorcontrib><creatorcontrib>FITZGERALD, RUSSELL</creatorcontrib><creatorcontrib>SHARP, MATTHEW JUDE</creatorcontrib><creatorcontrib>ELITZIN, VASSIL</creatorcontrib><creatorcontrib>ZHOU, XIAOMING</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SUTTON, PETER W</au><au>TABET, ELIE AMINE</au><au>GRADDY, WILLIAM HAWTHORNE</au><au>MCKEOWN, ROBERT RAHN</au><au>BULLOCK, KAE MIYAKE</au><au>MITCHELL, MARK BRYAN</au><au>DESCHAMPS, NICOLE</au><au>MATSUOKA, RICHARD TADAO</au><au>FITZGERALD, RUSSELL</au><au>SHARP, MATTHEW JUDE</au><au>ELITZIN, VASSIL</au><au>ZHOU, XIAOMING</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR PREPARING PEPTIDE DEFORMYLASE INHIBITORS</title><date>2014-09-18</date><risdate>2014</risdate><abstract>The present invention relates to processes for making {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl) hydrazino]-3-oxopropyl}hydroxyformamide compounds of Formula (I), or pharmaceutically acceptable salts thereof and corresponding intermediates thereof, where such compounds are useful in the inhibition of bacterial peptide deformylase (PDF) activity and in treatment methods for bacterial infections.
Cette invention concerne des procédés de préparation de composés de {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3-oxopropyl}- hydroxyformamide de Formule (I), ou de sels pharmaceutiquement acceptables de ceux-ci et d'intermédiaires leur correspondant, lesdits composés étant utiles pour inhiber l'activité de la peptide déformylase (PDF) bactérienne et dans des méthodes destinées à traiter les infections bactériennes.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre |
| recordid | cdi_epo_espacenet_WO2014141181A1 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | PROCESS FOR PREPARING PEPTIDE DEFORMYLASE INHIBITORS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-16T06%3A48%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=SUTTON,%20PETER%20W&rft.date=2014-09-18&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO2014141181A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |