PROCESS FOR PREPARING PEPTIDE DEFORMYLASE INHIBITORS

The present invention relates to processes for making {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl) hydrazino]-3-oxopropyl}hydroxyformamide compounds of Formula (I), or pharmaceutically acceptable salts thereof and corresponding intermediates thereof, where such compounds are useful in the inhibition of...

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Bibliographische Detailangaben
Hauptverfasser:	SUTTON, PETER W, TABET, ELIE AMINE, GRADDY, WILLIAM HAWTHORNE, MCKEOWN, ROBERT RAHN, BULLOCK, KAE MIYAKE, MITCHELL, MARK BRYAN, DESCHAMPS, NICOLE, MATSUOKA, RICHARD TADAO, FITZGERALD, RUSSELL, SHARP, MATTHEW JUDE, ELITZIN, VASSIL, ZHOU, XIAOMING
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The present invention relates to processes for making {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl) hydrazino]-3-oxopropyl}hydroxyformamide compounds of Formula (I), or pharmaceutically acceptable salts thereof and corresponding intermediates thereof, where such compounds are useful in the inhibition of bacterial peptide deformylase (PDF) activity and in treatment methods for bacterial infections. Cette invention concerne des procédés de préparation de composés de {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3-oxopropyl}- hydroxyformamide de Formule (I), ou de sels pharmaceutiquement acceptables de ceux-ci et d'intermédiaires leur correspondant, lesdits composés étant utiles pour inhiber l'activité de la peptide déformylase (PDF) bactérienne et dans des méthodes destinées à traiter les infections bactériennes.