SELECTIVE HISTONE DEACETYLASE 8 INHIBITORS

Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of histone deacetylase 8 (HDAC8). Also described herein are methods of using such HDAC8 inhibitors, alone and in combination with other compounds, for treating diseases or conditions...

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Bibliographische Detailangaben
Hauptverfasser: BRADNER, JAMES E, INGHAM, OSCAR J, BEELER, AARON BEATY, PORCO, JOHN A. JR
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of histone deacetylase 8 (HDAC8). Also described herein are methods of using such HDAC8 inhibitors, alone and in combination with other compounds, for treating diseases or conditions that benefit from inhibition of HDAC8 activity La présente invention concerne des composés, ainsi que des compositions pharmaceutiques contenant lesdits composés, qui inhibent l'activité de l'histone désacétylase 8 (HDAC8). L'invention concerne également des procédés d'utilisation desdits inhibiteurs de l'HDAC8, seuls et en association avec d'autres composés, en vue du traitement de maladies ou d'affections pouvant bénéficier de l'inhibition de l'activité de l'HDAC8.