DIPEPTIDE-REPEAT PROTEINS AS THERAPEUTIC TARGET IN NEURODEGENERATIVE DISEASES WITH HEXANUCLEOTIDE REPEAT EXPANSION
The present invention relates to a method of detecting a disease characterized by an expansion of genomic hexanucleotide repeats as well as polypeptides of said hexanucleotide repeats, ligands specifically binding to the polypeptide, methods of identifying an inhibitor preventing the expression and/...
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| creator | WENG, SHIH-MING EDBAUER, DIETER MORI, KOHJI HAASS, CHRISTIAN KREMMER, ELISABETH ARZTBERGER, THOMAS |
| description | The present invention relates to a method of detecting a disease characterized by an expansion of genomic hexanucleotide repeats as well as polypeptides of said hexanucleotide repeats, ligands specifically binding to the polypeptide, methods of identifying an inhibitor preventing the expression and/or aggregation of said polypeptide.
La présente invention concerne un procédé de détection d'une maladie caractérisée par une expansion de répétitions hexanucléotidiques génomiques, ainsi que des polypeptides desdites répétitions hexanucléotidiques, des ligands se liant spécifiquement au polypeptide, des procédés d'identification d'un inhibiteur empêchant l'expression et/ou l'agrégation dudit polypeptide. |
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La présente invention concerne un procédé de détection d'une maladie caractérisée par une expansion de répétitions hexanucléotidiques génomiques, ainsi que des polypeptides desdites répétitions hexanucléotidiques, des ligands se liant spécifiquement au polypeptide, des procédés d'identification d'un inhibiteur empêchant l'expression et/ou l'agrégation dudit polypeptide.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING |
| title | DIPEPTIDE-REPEAT PROTEINS AS THERAPEUTIC TARGET IN NEURODEGENERATIVE DISEASES WITH HEXANUCLEOTIDE REPEAT EXPANSION |
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