DIPEPTIDE-REPEAT PROTEINS AS THERAPEUTIC TARGET IN NEURODEGENERATIVE DISEASES WITH HEXANUCLEOTIDE REPEAT EXPANSION

The present invention relates to a method of detecting a disease characterized by an expansion of genomic hexanucleotide repeats as well as polypeptides of said hexanucleotide repeats, ligands specifically binding to the polypeptide, methods of identifying an inhibitor preventing the expression and/...

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Bibliographische Detailangaben
Hauptverfasser:	WENG, SHIH-MING, EDBAUER, DIETER, MORI, KOHJI, HAASS, CHRISTIAN, KREMMER, ELISABETH, ARZTBERGER, THOMAS
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The present invention relates to a method of detecting a disease characterized by an expansion of genomic hexanucleotide repeats as well as polypeptides of said hexanucleotide repeats, ligands specifically binding to the polypeptide, methods of identifying an inhibitor preventing the expression and/or aggregation of said polypeptide. La présente invention concerne un procédé de détection d'une maladie caractérisée par une expansion de répétitions hexanucléotidiques génomiques, ainsi que des polypeptides desdites répétitions hexanucléotidiques, des ligands se liant spécifiquement au polypeptide, des procédés d'identification d'un inhibiteur empêchant l'expression et/ou l'agrégation dudit polypeptide.