MONOSPECIFIC ANTI-HGF AND ANTI-ANG2 ANTIBODIES AND BISPECIFIC ANTI-HGF/ANTI-ANG2 ANTIBODIES

An antibody comprising a human angiopoietin-2 (ANG2) or human hepatocyte growth factor (HGF) recognition region is disclosed. Bispecific antibodies are also disclosed which comprises a first antigen-binding site that specifically binds to HGF and a second antigen-binding site that specifically binds...

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Bibliographische Detailangaben
Hauptverfasser:	BENHAR, ITAI, HAKIM, RAHEL, NOIMAN, SILVIA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	An antibody comprising a human angiopoietin-2 (ANG2) or human hepatocyte growth factor (HGF) recognition region is disclosed. Bispecific antibodies are also disclosed which comprises a first antigen-binding site that specifically binds to HGF and a second antigen-binding site that specifically binds to ANG2. Uses thereof and compositions comprising same are also disclosed. L'invention concerne un anticorps comprenant une région de reconnaissance d'angiopoïétine-2 humaine (ANG2) ou du facteur de croissance d'hépatocytes humain (HGF). L'invention concerne également des anticorps bispécifiques qui comprennent un premier site de liaison à un antigène qui se lie spécifiquement à HGF et un second site de liaison à un antigène qui se lie spécifiquement à ANG2. L'invention concerne également des utilisations de ceux-ci et des compositions les comprenant.