TROMETHAMINE SALT OF BIMATOPROST ACID IN CRYSTALLINE FORM, METHODS FOR PREPARATION, AND METHODS FOR USE THEREOF

The present invention provides tromethamine salt of 7-[3,5-Dihydroxy-2-(3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid in crystalline and amorphous form. This compound is may also be referred to as "tromethamine salt of bimatoprost acid." The invention crystalline form is u...

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Bibliographische Detailangaben
Hauptverfasser:	SMITH, SCOTT W, DUBAS-FISHER, FIONA, ST. CLAIR BROWN, ADRIAN, KARAMI, THOMAS K
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides tromethamine salt of 7-[3,5-Dihydroxy-2-(3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid in crystalline and amorphous form. This compound is may also be referred to as "tromethamine salt of bimatoprost acid." The invention crystalline form is useful for solid ocular implant or topical formulations, utilized in the treatment of various ocular conditions, such as, for example, ocular hypertension. La présente invention concerne un sel de trométhamine d'acide 7-[3,5-dihydroxy-2-(3-hydroxy-5-phényl-pent-1-ényl)-cyclopentyl]-hept-5-énoïque sous forme cristalline et sous forme amorphe. Ce composé peut également être dénommé « sel de trométhamine d'acide de bimatoprost ». La forme cristalline selon l'invention se révèle utile pour des formulations solides d'implant oculaire ou des formulations topiques, utilisées pour le traitement de diverses pathologies oculaires, telles que, par exemple, l'hypertension oculaire.