ALDEHYDE DERIVATIVE OF SUBSTITUTE OXAZOLIDINONES

The present invention concern towards the prodrug of 5-chloro-N-({(5S)-2-oxo-3-[4-(3- oxo-morpholin-4-yl)phenyl]-l,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, rivaroxaban per se; processes for their preparation, and the application in treatment and/or prophylaxis of diseases, especially of thr...

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Bibliographische Detailangaben
Hauptverfasser:	NILESH, SUDHIR PATIL, NITIN, SHARADCHANDRA PRADHAN, RAJESH, RAMCHANDRA WALAVALKAR, NILESH, SUBHAS KULKARNI, SANDIP, BABANRAO PAWAR, TARAK, SAMBHAJI PAWAR
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention concern towards the prodrug of 5-chloro-N-({(5S)-2-oxo-3-[4-(3- oxo-morpholin-4-yl)phenyl]-l,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, rivaroxaban per se; processes for their preparation, and the application in treatment and/or prophylaxis of diseases, especially of thromboembolic disorders. The prodrug of compound formula (B) is chemically designated as5-chloro-N-formyl-N-({(5S)-2-oxo-3-[4-(3- oxomorpholin-4-yl)phenyl]- l,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide.(I) Cette invention concerne le promédicament du 5-chloro-N-({(5S)-2-oxo-3- [4-(3-oxo-morpholin-4-yl)phényl]-l,3-oxazolidin-5-yl}méthyl)thiophène- 2-carboxamide, à savoir le rivaroxaban lui-même ; leurs procédés de préparation et leur utilisation pour traiter et/ou prévenir des maladies, notamment les troubles thromboemboliques. Le promédicament du composé de formule (B) est chimiquement désigné 5-chloro-N-formyl-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phényl]-l,3-oxazolidin-5-yl}méthyl)thiophène- 2-carboxamide.(I)