PROCESS FOR MAKING REVERSE TRANSCRIPTASE INHIBITORS

The present invention is directed to a novel process for synthesizing 3-(substituted phenoxy)-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl])-pyridin-2(1H)-one derivatives. The compounds synthesized by the processes of the invention are HIV reverse transcriptase inhibitors useful for inhibiting...

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Bibliographische Detailangaben
Hauptverfasser:	MANGION, IAN, JEON, INGYU, SHERRY, BENJAMIN, D, QIAN, GANG, GAUTHIER, DONALD, R, CAO, YANG, ITOH, TETSUJI
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention is directed to a novel process for synthesizing 3-(substituted phenoxy)-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl])-pyridin-2(1H)-one derivatives. The compounds synthesized by the processes of the invention are HIV reverse transcriptase inhibitors useful for inhibiting reverse transcriptase, HIV replication and the treatment of human immunodeficiency virus infection in humans. La présente invention concerne un nouveau procédé pour synthétiser la 1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazole-3-yl)méthyl])-pyridin-2(1H)-one 3-phénoxy-substituée. Les composés synthétisés par les procédés de l'invention sont des inhibiteurs de transcriptase inverse du VIH utiles pour l'inhibition de la transcriptase inverse, la réplication du VIH et le traitement d'une infection par le virus d'immunodéficience humaine chez des humains.