N-SUBSTITUTED INDAZOLE SULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS

Disclosed are compounds of Formula AA and Formula AB: wherein "Heteroaryl-1", RA1, RA2, RB1, and RC are defined herein, which novel compounds have properties for blocking Nav 1.7 ion channels found in peripherial and sympathetic neurons. Also described are pharmaceutical formulations compr...

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Bibliographische Detailangaben
Hauptverfasser:	ROSSI, MICHAEL, A, LAYTON, MARK, E, KELLY, MICHAEL, J., III, LEHMAN, HANNAH, D. G. F, PERO, JOSEPH, E
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	Disclosed are compounds of Formula AA and Formula AB: wherein "Heteroaryl-1", RA1, RA2, RB1, and RC are defined herein, which novel compounds have properties for blocking Nav 1.7 ion channels found in peripherial and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formulae AA and AB or their salts, and methods of treating neuropathic pain disorders using the same. L'invention concerne des composés de formule AA et de formule AB : dans lesquelles "Hétéroaryl-1", RA1, RA2, RB1 et RC sont définis ici, ces nouveaux composés ayant des propriétés de blocage des canaux ioniques Nav 1.7 qui se trouvent dans les neurones périphériques et sympathiques. L'invention concerne également des formulations pharmaceutiques comprenant les composés de formules AA et AB ou leurs sels, ainsi que des procédés de traitement de troubles de douleur neuropathique les employant.