2'-METHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES

2'-METHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES

The present invention relates to 2'-Methyl Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R, R1, R2 and R3, are as defined herein. The present invention also relates to compositions comprising at least one 2'-Methyl Substituted Nuc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HONG, QINGMEI, DAVIES, IAN, TRUONG, QUANG, T, BENNETT, FRANK, BOGEN, STEPHANE, CHEN, PING, GIRIJAVALLABHAN, VINAY, KEREKES, ANGELA, ESPOSITE, SARA
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Beschreibung
Zusammenfassung:The present invention relates to 2'-Methyl Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R, R1, R2 and R3, are as defined herein. The present invention also relates to compositions comprising at least one 2'-Methyl Substituted Nucleoside Derivative, and methods of using the 2'-Methyl Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient. La présente invention concerne des dérivés de nucléosides 2'-méthyle substitués de la formule (I) : (I) et des sels pharmaceutiquement acceptables de ceux-ci, R, R1, R2, R3 étant tels que définis par les présentes. La présente invention concerne également des compositions qui comportent au moins un dérivé de nucléoside 2'-méthyle substitué, et des procédés d'utilisation des dérivés de nucléosides 2-méthyle substitués pour le traitement ou la prévention d'une infection par le VHC chez un patient.