ARSENOPLATIN ANTI-CANCER AGENTS

Disclosed are compound having the structure of formula (I): wherein M is Pt, Pd or Ni; Q is As, Sb or Bi; Z1 is N; Z2 is O or S; L1 and L2 are independently C(O), C-R1 or C-R2; X is a Lewis base and Y1 and Y2 are independently oxygen- or sulfur-containing substituents, conjugates containing compound...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	O'HALLORAN, THOMAS, V, MIODRAGOVIC, DENANA, U
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Disclosed are compound having the structure of formula (I): wherein M is Pt, Pd or Ni; Q is As, Sb or Bi; Z1 is N; Z2 is O or S; L1 and L2 are independently C(O), C-R1 or C-R2; X is a Lewis base and Y1 and Y2 are independently oxygen- or sulfur-containing substituents, conjugates containing compounds of formula (I) and their use as chemotherapy agents. L'invention concerne un composé ayant la structure de formule (I) : dans laquelle M représente Pt, Pd ou Ni ; Q représente As, Sb ou Bi ; Z1 représente N ; Z2 représente O ou S ; L1 et L2 représentent indépendamment C(O), C-R1 ou C-R2 ; X est une base de Lewis et Y1 et Y2 représentent indépendamment des substituants contenant de l'oxygène ou du soufre, des conjugués contenant les composés de formule (I) et leur utilisation comme agents de chimiothérapie.