NT-proCNP AS A BIOMARKER OF VASCULAR DISORDERS AND PREGNANCY COMPLICATION

The present disclosure relates to methods for the prognosis and/or diagnosis of vascular-related disorders in a subject and in particular pregnancy-related vascular disorders. The present disclosure is based on the finding that a positive correlation exists between positive prediction of a vascular...

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Bibliographische Detailangaben
Hauptverfasser:	PRICKETT, TIMOTHY CHARLES RAMSEY, ESPINER, ERIC ARNOLD
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TESTING
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Beschreibung
Zusammenfassung:	The present disclosure relates to methods for the prognosis and/or diagnosis of vascular-related disorders in a subject and in particular pregnancy-related vascular disorders. The present disclosure is based on the finding that a positive correlation exists between positive prediction of a vascular disorder event in a subject and the concentration of the circulating marker NTproCNP (also referred to as NT-CNP) in humans and animals. In addition, the present disclosure is based on the finding that there is also a positive correlation between the occurrence of a vascular-related adverse event during pregnancy and the concentration of the circulating marker NTproCNP in the maternal circulation. Cette invention concerne des méthodes destinées à pronostiquer et/ou à diagnostiquer des troubles de type vasculaire chez un sujet et en particulier des troubles vasculaires liés à la grossesse. Cette invention se base sur la découverte selon laquelle il existe une corrélation positive entre la prédiction positive d'un événement de type trouble vasculaire chez un sujet et la concentration du marqueur NTproCNP circulant (également appelé NT-CNP) chez l'homme et l'animal. De plus, cette invention se base sur la découverte selon laquelle il existe également une corrélation positive entre l'occurrence d'un événement indésirable de type vasculaire pendant la grossesse et la concentration du marqueur NTproCNP circulant dans la circulation maternelle.