2-CARBAMO(THIO)YL-1,3- DIOXOPROPYL DERIVATIVES IN CANCER THERAPY

Certain 2-carbamo(thio)yl-1,3-dioxopropyl derivatives, or the tautomers and pharmacologically acceptable addition salts thereof are found to be toxic to cancer cells, in part, by inhibiting DNA topoisomerase II enzyme making them candidates for pharmaceutical use as anticancer agents. Certains dériv...

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Hauptverfasser:	HASINOFF, BRIAN B, CHEE, GAIK-LEAN, BREWER, A. DAVID
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Certain 2-carbamo(thio)yl-1,3-dioxopropyl derivatives, or the tautomers and pharmacologically acceptable addition salts thereof are found to be toxic to cancer cells, in part, by inhibiting DNA topoisomerase II enzyme making them candidates for pharmaceutical use as anticancer agents. Certains dérivés 2-carbamo(thio)yl-1,3-dioxopropylés, ou les tautomères et sels d'addition pharamacologiquement acceptables de ceux-ci sont trouvés comme étant toxiques vis-à-vis de cellules cancéreuses, en partie, par l'inhibition de l'enzyme ADN topoisomérase II, faisant de ceux-ci des candidats pour une utilisation pharmaceutique comme agents anti-cancéreux.