PATHOGEN DETECTION USING METAL ENHANCED FLUORESCENCE

Pathogen sensors, systems for pathogen detection, peptide ligands, and methods for detecting pathogens are disclosed. The pathogen sensors include silver particles attached to optically clear substrates, immobilized capture peptide or glycan ligands attached to the silver particles, and free labelin...

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Bibliographische Detailangaben
Hauptverfasser:	TOMCZAK, MELANIE, SMITH, CLINT, B, LIPTAK, DAVID, C, OSTENDORF, MELINDA, A
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE TESTING
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Beschreibung
Zusammenfassung:	Pathogen sensors, systems for pathogen detection, peptide ligands, and methods for detecting pathogens are disclosed. The pathogen sensors include silver particles attached to optically clear substrates, immobilized capture peptide or glycan ligands attached to the silver particles, and free labeling peptide or glycan ligands having fluorophores. Binding of the immobilized capture ligands and the free labeling ligands to the pathogen positions the fluorophore at a distance from the silver particles sufficient to initiate metal enhanced fluorescence. L'invention concerne des capteurs de pathogènes, des systèmes destinés à la détection de pathogènes, des ligands peptidiques et des procédés destinés à la détection de pathogènes. Les capteurs de pathogènes incluent des particules d'argent fixées à des substrats optiquement transparents, un peptide de capture ou des ligands de type glycane immobilisé(s), fixé(s) aux particules d'argent et un peptide ou des ligands de type glycane de marquage libre(s) comportant des fluorophores. La liaison des ligands de capture immobilisés et des ligands de marquage libres au pathogène positionne le fluorophore à une distance suffisante des particules d'argent pour initier la fluorescence augmentée par le métal.