A NOVEL PROCESS FOR THE PREPARATION OF SITAGLIPTIN

The present invention is directed to a process for the preparation of enantiomerically enriched beta-amino acid derivatives which are important chiral building blocks and intermediates in pharmaceuticals. More specifically, the invention pertains to a novel process for practically convenient and eco...

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Bibliographische Detailangaben
Hauptverfasser:	MALLELA, SAMBHU, PRASAD, SARMA, HAVALE, SHRIKANT, HANUMANTAPPA, BODDEPALLI, NAGABHUSHANA, RAO, GUNJI, NAGARJUNA, MOKKAPATI, BHAVANI, SANKAR
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The present invention is directed to a process for the preparation of enantiomerically enriched beta-amino acid derivatives which are important chiral building blocks and intermediates in pharmaceuticals. More specifically, the invention pertains to a novel process for practically convenient and economically producing enantiomerically enriched beta-amino acid derivatives which are useful for the synthesis of amide inhibitors of dipeptidyl peptidase IV like Sitagliptin, which have been used to treat type 2 diabetes. La présente invention concerne un procédé de préparation de dérivés de beta-aminoacides enrichis énantiomériquement qui sont des blocs de construction et des intermédiaires chiraux importants dans des produits pharmaceutiques. De manière plus spécifique, l'invention concerne un nouveau procédé de production pratique et économique de dérivés de beta-aminoacides enrichis énantiomériquement, utiles pour la synthèse d'inhibiteurs de type amide de la dipeptidyle peptidase IV, analogues à la sitagliptine, qui ont été utilisés pour traiter le diabète de type 2.