PHARMACEUTICAL COMPOSITIONS CONTAINING ANG-(1-7) OR ANOTHER MAS RECEPTOR AGONIST IN COMBINATION WITH PI3K/AKT INHIBITORS FOR THERAPEUTIC ANTI-CANCER TREATMENT

The present invention describes pharmaceutical compositions containing a combination of Ang-(1-7) or another Mas receptor agonist with PI3K/Akt, for therapeutic anti-cancer treatment. The combination of Ang-(1-7) and PI3K/Akt inhibitors inhibits progression of the cancer by inhibiting cell growth or...

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Hauptverfasser:	AUGUSTO SOUZA DOS SANTOS, ROBSON, GOMES PASSOS SILVA, DANIELLE, VERANO BRAGA, THIAGO, ROEPSTORFF, PETER, JEAN GEORGES FREZARD, FREDERIC
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Sprache:	eng ; fre ; por
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	AUGUSTO SOUZA DOS SANTOS, ROBSON GOMES PASSOS SILVA, DANIELLE VERANO BRAGA, THIAGO ROEPSTORFF, PETER JEAN GEORGES FREZARD, FREDERIC
description	The present invention describes pharmaceutical compositions containing a combination of Ang-(1-7) or another Mas receptor agonist with PI3K/Akt, for therapeutic anti-cancer treatment. The combination of Ang-(1-7) and PI3K/Akt inhibitors inhibits progression of the cancer by inhibiting cell growth or proliferation or by activating cell death by apoptosis in mammals, particularly in humans. La présente invention concerne des compositions pharmaceutiques contenant une combinaison d'Ang-(1-7) ou d'un autre agoniste du récepteur Mas avec des inhibiteurs PI3K/Akt, pour le traitement thérapeutique anticancer. La combinaison d'Ang-(1-7) et d'inhibiteurs de PI3K/Akt provoque l'inhibition de la progression du cancer par inhibition de la croissance ou de la prolifération cellulaire, ou l'activation de la mort cellulaire par apoptose chez des mammifères, et notamment chez l'être humain. A presente invenção descreve composições farmacêuticas contendo uma combinação de Ang-(1-7) ou outro agonista do receptor Mas com inibidores de PI3K/Akt, para o tratamento terapêutico anticâncer. A combinação de Ang-(1-7) e inibidores de PI3K/Akt acarreta a inibição da progressão do câncer através da inibição do crescimento ou proliferação celular ou a ativação da morte celular por apoptose em mamíferos, particularmente em humanos.
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The combination of Ang-(1-7) and PI3K/Akt inhibitors inhibits progression of the cancer by inhibiting cell growth or proliferation or by activating cell death by apoptosis in mammals, particularly in humans. La présente invention concerne des compositions pharmaceutiques contenant une combinaison d'Ang-(1-7) ou d'un autre agoniste du récepteur Mas avec des inhibiteurs PI3K/Akt, pour le traitement thérapeutique anticancer. La combinaison d'Ang-(1-7) et d'inhibiteurs de PI3K/Akt provoque l'inhibition de la progression du cancer par inhibition de la croissance ou de la prolifération cellulaire, ou l'activation de la mort cellulaire par apoptose chez des mammifères, et notamment chez l'être humain. A presente invenção descreve composições farmacêuticas contendo uma combinação de Ang-(1-7) ou outro agonista do receptor Mas com inibidores de PI3K/Akt, para o tratamento terapêutico anticâncer. A combinação de Ang-(1-7) e inibidores de PI3K/Akt acarreta a inibição da progressão do câncer através da inibição do crescimento ou proliferação celular ou a ativação da morte celular por apoptose em mamíferos, particularmente em humanos.</description><language>eng ; fre ; por</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2013</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130704&DB=EPODOC&CC=WO&NR=2013097017A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130704&DB=EPODOC&CC=WO&NR=2013097017A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>AUGUSTO SOUZA DOS SANTOS, ROBSON</creatorcontrib><creatorcontrib>GOMES PASSOS SILVA, DANIELLE</creatorcontrib><creatorcontrib>VERANO BRAGA, THIAGO</creatorcontrib><creatorcontrib>ROEPSTORFF, PETER</creatorcontrib><creatorcontrib>JEAN GEORGES FREZARD, FREDERIC</creatorcontrib><title>PHARMACEUTICAL COMPOSITIONS CONTAINING ANG-(1-7) OR ANOTHER MAS RECEPTOR AGONIST IN COMBINATION WITH PI3K/AKT INHIBITORS FOR THERAPEUTIC ANTI-CANCER TREATMENT</title><description>The present invention describes pharmaceutical compositions containing a combination of Ang-(1-7) or another Mas receptor agonist with PI3K/Akt, for therapeutic anti-cancer treatment. 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The combination of Ang-(1-7) and PI3K/Akt inhibitors inhibits progression of the cancer by inhibiting cell growth or proliferation or by activating cell death by apoptosis in mammals, particularly in humans. La présente invention concerne des compositions pharmaceutiques contenant une combinaison d'Ang-(1-7) ou d'un autre agoniste du récepteur Mas avec des inhibiteurs PI3K/Akt, pour le traitement thérapeutique anticancer. La combinaison d'Ang-(1-7) et d'inhibiteurs de PI3K/Akt provoque l'inhibition de la progression du cancer par inhibition de la croissance ou de la prolifération cellulaire, ou l'activation de la mort cellulaire par apoptose chez des mammifères, et notamment chez l'être humain. A presente invenção descreve composições farmacêuticas contendo uma combinação de Ang-(1-7) ou outro agonista do receptor Mas com inibidores de PI3K/Akt, para o tratamento terapêutico anticâncer. A combinação de Ang-(1-7) e inibidores de PI3K/Akt acarreta a inibição da progressão do câncer através da inibição do crescimento ou proliferação celular ou a ativação da morte celular por apoptose em mamíferos, particularmente em humanos.</abstract><oa>free_for_read</oa></addata></record>
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title	PHARMACEUTICAL COMPOSITIONS CONTAINING ANG-(1-7) OR ANOTHER MAS RECEPTOR AGONIST IN COMBINATION WITH PI3K/AKT INHIBITORS FOR THERAPEUTIC ANTI-CANCER TREATMENT
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