VARIANT FC-POLYPEPTIDES WITH ENHANCED BINDING TO THE NEONATAL FC RECEPTOR

Described herein are variant Fc-fragments that contain an insertion within or adjacent to a loop that bind to the neonatal Fc receptor (FcRn) with higher affinity and/or higher binding activity at pH 5-6 and approximately the same or lower affinity at a physiologic pH as compared to a control Fc-fra...

Ausführliche Beschreibung

Bibliographische Detailangaben

Hauptverfasser:	HARRIS, SUSIE M, RETTER, MARK W, MICHAELS, MARK L, LU, JI, KET, RANDAL R, SUN, JEONGHOON, HAN, SEOG JOON, TSAI, MEI-MEI
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES
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