''3-(5-METHYL-2-OXO-L, 3-DIOXOL-4-YL) METHYLOXY-2- TRANS-[(4-CHLORO PHENYL) CYCLOHEXYL] [1,4]NAPHTHAQUINONE"-ATOVAQUONE PRODRUG
The present invention relates to atovaquone prodrug compound of formula (I). Accordingly, present invention provides a process involving condensation of Atovaquone (II) with 5-methyl-4- chloromethyl dioxalone (III) in suitable solvent system and optionally followed by distillation and crystallizatio...
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| creator | AKSHAYA KUNJYANNAYA SHASHIPRABHA SHRIDHARA KANAKAMAJALU KUPPUSWAMY NAGARAJAN SANJAY SUKUMAR SARALAYA KOTHAPALLI SUNDARRAJA RAO |
| description | The present invention relates to atovaquone prodrug compound of formula (I). Accordingly, present invention provides a process involving condensation of Atovaquone (II) with 5-methyl-4- chloromethyl dioxalone (III) in suitable solvent system and optionally followed by distillation and crystallization to provide Atovaquone prodrug compound of formula (I) in high yields, purity, and suitable for large-scale manufacture.
La présente invention concerne un composé promédicament d'atovaquone de formule (I). Elle concerne un procédé qui consiste à condenser de l'atovaquone (II) avec de la 5-méthyl-4-chlorométhyl dioxalone (III) dans un système de solvant approprié, puis éventuellement à effectuer une distillation et une cristallisation afin d'obtenir un composé promédicament d'atovaquone de formule (I) à haut rendement, très pur, adapté à une production à grande échelle. |
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La présente invention concerne un composé promédicament d'atovaquone de formule (I). Elle concerne un procédé qui consiste à condenser de l'atovaquone (II) avec de la 5-méthyl-4-chlorométhyl dioxalone (III) dans un système de solvant approprié, puis éventuellement à effectuer une distillation et une cristallisation afin d'obtenir un composé promédicament d'atovaquone de formule (I) à haut rendement, très pur, adapté à une production à grande échelle.</description><language>eng ; fre</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2013</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130815&DB=EPODOC&CC=WO&NR=2013093937A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130815&DB=EPODOC&CC=WO&NR=2013093937A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>AKSHAYA KUNJYANNAYA</creatorcontrib><creatorcontrib>SHASHIPRABHA</creatorcontrib><creatorcontrib>SHRIDHARA KANAKAMAJALU</creatorcontrib><creatorcontrib>KUPPUSWAMY NAGARAJAN</creatorcontrib><creatorcontrib>SANJAY SUKUMAR SARALAYA</creatorcontrib><creatorcontrib>KOTHAPALLI SUNDARRAJA RAO</creatorcontrib><title>''3-(5-METHYL-2-OXO-L, 3-DIOXOL-4-YL) METHYLOXY-2- TRANS-[(4-CHLORO PHENYL) CYCLOHEXYL] [1,4]NAPHTHAQUINONE"-ATOVAQUONE PRODRUG</title><description>The present invention relates to atovaquone prodrug compound of formula (I). Accordingly, present invention provides a process involving condensation of Atovaquone (II) with 5-methyl-4- chloromethyl dioxalone (III) in suitable solvent system and optionally followed by distillation and crystallization to provide Atovaquone prodrug compound of formula (I) in high yields, purity, and suitable for large-scale manufacture.
La présente invention concerne un composé promédicament d'atovaquone de formule (I). Elle concerne un procédé qui consiste à condenser de l'atovaquone (II) avec de la 5-méthyl-4-chlorométhyl dioxalone (III) dans un système de solvant approprié, puis éventuellement à effectuer une distillation et une cristallisation afin d'obtenir un composé promédicament d'atovaquone de formule (I) à haut rendement, très pur, adapté à une production à grande échelle.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2013</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNirEKwjAURbs4iPoPQYcq9EFtKuIY2mgKMa_WVBukFJE4iRbq7q8b0Q9wuudyTt97-T6F6QK2XAsjIQKsEGRAKKSZQwkxGDkjX42VcQXRBVN7OE1jSITEAkkuuPpUiUkkCl4ZWZPTPIhrxXKhBduVmULFx8A0HtxzTPIC06LcDL3e9Xzr7Oi3A2-y5joRYNtHY7v2fLF3-2yOGIVzGq7oii4Zpf9Vb0PlO_s</recordid><startdate>20130815</startdate><enddate>20130815</enddate><creator>AKSHAYA KUNJYANNAYA</creator><creator>SHASHIPRABHA</creator><creator>SHRIDHARA KANAKAMAJALU</creator><creator>KUPPUSWAMY NAGARAJAN</creator><creator>SANJAY SUKUMAR SARALAYA</creator><creator>KOTHAPALLI SUNDARRAJA RAO</creator><scope>EVB</scope></search><sort><creationdate>20130815</creationdate><title>''3-(5-METHYL-2-OXO-L, 3-DIOXOL-4-YL) METHYLOXY-2- TRANS-[(4-CHLORO PHENYL) CYCLOHEXYL] [1,4]NAPHTHAQUINONE"-ATOVAQUONE PRODRUG</title><author>AKSHAYA KUNJYANNAYA ; SHASHIPRABHA ; SHRIDHARA KANAKAMAJALU ; KUPPUSWAMY NAGARAJAN ; SANJAY SUKUMAR SARALAYA ; KOTHAPALLI SUNDARRAJA RAO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2013093937A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2013</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>AKSHAYA KUNJYANNAYA</creatorcontrib><creatorcontrib>SHASHIPRABHA</creatorcontrib><creatorcontrib>SHRIDHARA KANAKAMAJALU</creatorcontrib><creatorcontrib>KUPPUSWAMY NAGARAJAN</creatorcontrib><creatorcontrib>SANJAY SUKUMAR SARALAYA</creatorcontrib><creatorcontrib>KOTHAPALLI SUNDARRAJA RAO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>AKSHAYA KUNJYANNAYA</au><au>SHASHIPRABHA</au><au>SHRIDHARA KANAKAMAJALU</au><au>KUPPUSWAMY NAGARAJAN</au><au>SANJAY SUKUMAR SARALAYA</au><au>KOTHAPALLI SUNDARRAJA RAO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>''3-(5-METHYL-2-OXO-L, 3-DIOXOL-4-YL) METHYLOXY-2- TRANS-[(4-CHLORO PHENYL) CYCLOHEXYL] [1,4]NAPHTHAQUINONE"-ATOVAQUONE PRODRUG</title><date>2013-08-15</date><risdate>2013</risdate><abstract>The present invention relates to atovaquone prodrug compound of formula (I). Accordingly, present invention provides a process involving condensation of Atovaquone (II) with 5-methyl-4- chloromethyl dioxalone (III) in suitable solvent system and optionally followed by distillation and crystallization to provide Atovaquone prodrug compound of formula (I) in high yields, purity, and suitable for large-scale manufacture.
La présente invention concerne un composé promédicament d'atovaquone de formule (I). Elle concerne un procédé qui consiste à condenser de l'atovaquone (II) avec de la 5-méthyl-4-chlorométhyl dioxalone (III) dans un système de solvant approprié, puis éventuellement à effectuer une distillation et une cristallisation afin d'obtenir un composé promédicament d'atovaquone de formule (I) à haut rendement, très pur, adapté à une production à grande échelle.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | ''3-(5-METHYL-2-OXO-L, 3-DIOXOL-4-YL) METHYLOXY-2- TRANS-[(4-CHLORO PHENYL) CYCLOHEXYL] [1,4]NAPHTHAQUINONE"-ATOVAQUONE PRODRUG |
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