AMINOPYRIMIDINONES AS INTERLEUKIN RECEPTOR-ASSOCIATED KINASE INHIBITORS

This invention relates to aminopyrimidinone compounds of Formula (I) that are inhibitors of Interleukin receptor-associated kinases, in particular IRAK-4, and are useful in the treatment or prevention of inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease. La présent...

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Bibliographische Detailangaben
Hauptverfasser:	TULSHIAN, DEAN, B, GIBEAU, CRAIG, R, SEGANISH, W. MICHAEL, MCELROY, WILLIAM, T, LAVEY, BRIAN, J, MATASI, JULIUS, J, BRUMFIELD, STEPHANIE NICOLE, LIM, JONGWON, ALTMAN, MICHAEL, D, METHOT, JOEY, ZHU, LIANG, LAMPE, JOHN WILLIAM
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY FISHING FORESTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF TRAPPING
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Beschreibung
Zusammenfassung:	This invention relates to aminopyrimidinone compounds of Formula (I) that are inhibitors of Interleukin receptor-associated kinases, in particular IRAK-4, and are useful in the treatment or prevention of inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease. La présente invention concerne des composés aminopyrimidinone de formule (I) qui sont des inhibiteurs des kinases associées au récepteur de l'interleukine, en particulier IRAK-4, et qui sont utiles dans le traitement ou la prévention de maladies inflammatoires, y compris de la polyarthrite rhumatoïde et d'une affection abdominale inflammatoire.