PROCESS FOR THE PREPARATION OF OLMESARTAN MEDOXOMIL

The present invention provides novel process for preparation of olmesartan medoxomil (I) substantially free of olmesartan acid impurity (II) comprising, reacting trityl olmesartan medoxomil (III) with acid, filtering the precipitate of trityl alcohol, subjecting the filtrate to agitated thin film dr...

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Bibliographische Detailangaben
Hauptverfasser:	SINGH, GIRIJ, PAL, GODBOLE, HIMANSHU, MADHAV, FIRKE, RAJENDRA, VISWANATH, BHANGALE, CHANDRAKANT,SHRIRAM, SISODIA, UJJWAL,KOMALSINGH, SHIVDAVKAR, RADHAKRISHNA, BHIKAJI
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The present invention provides novel process for preparation of olmesartan medoxomil (I) substantially free of olmesartan acid impurity (II) comprising, reacting trityl olmesartan medoxomil (III) with acid, filtering the precipitate of trityl alcohol, subjecting the filtrate to agitated thin film drying and recovering olmesartan medoxomil (I). La présente invention concerne un nouveau procédé de préparation d'olmésartan médoxomil (I) sensiblement exempt d'impureté acide d'olmésartan (II), ledit procédé consistant à faire réagir l'olmésartan médoxomil tritylé (III) avec un acide, à filtrer le précipité d'alcool tritylé, à soumettre le filtrat à un séchage sur couche mince en mouvement et à récupérer l'olmésartan médoxomil (I).