TUNING OF FUSEL ALCOHOL BY-PRODUCTS DURING ISOBUTANOL PRODUCTION BY RECOMBINANT MICROORGANISMS

The disclosure relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects, the recombinant microorganisms may further comprise one or more modifications resulting in the red...

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Hauptverfasser:	FELDMAN, REID, M, HAWKINS, ANDREW, C, URANO, JUN, MEINHOLD, PETER, PETERS, MATTHEW, W
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGYGENERATION, TRANSMISSION OR DISTRIBUTION SPIRITS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE VINEGAR WINE
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Beschreibung
Zusammenfassung:	The disclosure relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of a 2-ketoisovalerate-derived by-product such as 3-methyl-1-butanol. The recombinant microorganisms may be microorganisms of the Saccharomyces dade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms. La présente invention concerne des micro-organismes recombinants comprenant des voies de biosynthèse et des procédés d'utilisation desdits micro-organismes recombinants pour produire différents métabolites bénéfiques. Dans différents aspects de l'invention, les micro-organismes recombinants peuvent comprendre en outre une ou plusieurs modifications conduisant à la réduction ou l'élimination d'un sous-produit dérivé de 2-cétoisovalérate tel que le 3-méthyl-1-butanol. Les micro-organismes recombinants peuvent être des micro-organismes du clade Saccharomyces, des micro-organismes de levure Crabtree négatif, des micro-organismes de levure Crabtree positif, des micro-organismes de levure post-WGD (duplication du génome total), des micro-organismes de levure pré-WGD (duplication du génome total), et des micro-organismes de levure non fermenteurs.