NOVEL SALT INTERMEDIATES FOR THE SYNTHESIS OF BAZEDOXIFENE ACETATE AND PROCESS THEREOF

NOVEL SALT INTERMEDIATES FOR THE SYNTHESIS OF BAZEDOXIFENE ACETATE AND PROCESS THEREOF

The present invention relates to novel salts of 1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-H-indole which are useful intermediates in the production of (1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1-H- indol-5-ol acetic acid commonly known...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LUTHRA, PARVEN, KUMAR, NAIR, RAJI, SALUNKE, SANJUKUMAR, BHUTA, SACHIN, VENKATARAMAN, DEEPAK
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to novel salts of 1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-H-indole which are useful intermediates in the production of (1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1-H- indol-5-ol acetic acid commonly known as bazedoxifene acetate and related compounds. La présente invention concerne de nouveaux sels de 1-[4-(2-azépan-1-yl-éthoxy)-benzyl]-5-benzyloxy-2-(4-benzyloxyphényl)-3-méthyl-1-H-indole qui sont des intermédiaires utiles dans la préparation de l'acide (1-[4-(2-azépan-1-yl-éthoxy)-benzyl]-2-(4-hydroxyphényl)-3-méthyl-1-H-indol-5-ol acétique communément connu comme acétate de bazedoxifène, et des composés associés.