IMPROVED PROCESS FOR PREPARING CYCLOPENTYLAMINE DERIVATIVES AND INTERMEDIATES THEREOF

IMPROVED PROCESS FOR PREPARING CYCLOPENTYLAMINE DERIVATIVES AND INTERMEDIATES THEREOF

Disclosed herein is an improved process for the preparation of substituted cyclopentanamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Particularly described is an improved, commercially viable and industrially advantageous process for the...

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Bibliographische Detailangaben
Hauptverfasser: NAIR, VIGNESH, PRADHAN, NITIN, SHARADCHANDRA, TRIVEDI, NIKHIL, KHILE, ANIL, SHAHAJI
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Disclosed herein is an improved process for the preparation of substituted cyclopentanamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Particularly described is an improved, commercially viable and industrially advantageous process for the preparation of a ticagrelor intermediate, [3aR-(3aa,4a,6a,6aa]-2-[[6-amino-2,2-dimethyltetrahydro-4H-cyclopenta-1,3-dioxol-4- yl]oxy]-ethanol, alternatively named, 2-[[(3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro- 3aH-cyclopenta[d] [1,3] -dioxol-4-yl]oxy] -1-ethanol. La présente invention concerne un procédé amélioré de préparation de dérivés de cyclopentanamine substituée, qui sont des intermédiaires utiles dans la préparation de composés de triazolo[4,5-d]pyrimidine. En particulier, l'invention concerne un procédé amélioré, commercialement viable et industriellement avantageux de préparation d'un intermédiaire du ticagrelor, le [3aR-(3aa,4a,6a,6aa]-2-[[6-amino-2,2-diméthyltétrahydro-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-éthanol, appelé également 2-[[(3aR,4S,6R,6aS)-6-amino-2,2-diméthyltétrahydro-3aH-cyclopenta[d][1,3]-dioxol-4-yl]oxy]-1-éthanol.