LIPHAGAL ENANTIOMERS AND THEIR DERIVATIVES AND PRECURSORS, AND ENANTIOSELECTIVE METHODS OF MAKING THE SAME

LIPHAGAL ENANTIOMERS AND THEIR DERIVATIVES AND PRECURSORS, AND ENANTIOSELECTIVE METHODS OF MAKING THE SAME

Enantioenriched compositions of liphagal and its derivatives and precursors include more than 50 mol% of a first enantiomer based on the total amount of a first and a second enantiomer. A method of making an enantioenriched composition includes catalytic enantioselective alkylation, ring expansion,...

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Bibliographische Detailangaben
Hauptverfasser: STOLTZ, BRIAN, M, VIRGIL, SCOTT, C, ALLEVA, JENNIFER, L, MCFADDEN, RYAN, DAY, JOSHUA, J, KOLDING, HELENE
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Enantioenriched compositions of liphagal and its derivatives and precursors include more than 50 mol% of a first enantiomer based on the total amount of a first and a second enantiomer. A method of making an enantioenriched composition includes catalytic enantioselective alkylation, ring expansion, and intramolecular aryne cylization. L'invention concerne des compositions de liphagal enrichies en énantiomères et ses dérivés et précurseurs comprenant plus de 50% molaire d'un premier énantiomère sur la base de la quantité totale d'un premier et d'un second énantiomère. L'invention concerne également un procédé de fabrication d'une composition enrichie en énantiomère comprenant une alkylation catalytique énantiosélective, une expansion de cycle et une cyclisation d'aryne intramoléculaire.