NOVEL PROCESS FOR PREPARATION OF ESLICARBAZEPINE

NOVEL PROCESS FOR PREPARATION OF ESLICARBAZEPINE

Disclosed are a process for the preparation of (S)-(+)-10,ll-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide (eslicarbazepine), (S)-(-)-10-(acetyloxy)-10,ll-dihydro-5H-dibenz[b,f]azepine-5-carboxamide (eslicarbazepine acetate) and novel compounds that may be useful intermediates in the prepar...

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Bibliographische Detailangaben
Hauptverfasser: GHARPURE, MILIND MORESHWAR, THANEDAR, AMIT ANANT, RANE, DNYANDEV, ZOPE, SUNIL SUDHAKAR, NARAWADE, KRISHNA BABAN
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Disclosed are a process for the preparation of (S)-(+)-10,ll-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide (eslicarbazepine), (S)-(-)-10-(acetyloxy)-10,ll-dihydro-5H-dibenz[b,f]azepine-5-carboxamide (eslicarbazepine acetate) and novel compounds that may be useful intermediates in the preparation thereof. L'invention concerne un procédé pour préparer les composés (S)-(+)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azépine-5-carboxamide(eslicarbazépine), (S)-(-)-10-(acétyloxy)-10,11-dihydro-5H-dibenz[b,f]-azépine-5-carboxamide (acétate d'eslicarbazépine) ainsi que des nouveaux composés pouvant être des intermédiaires utiles lors de la préparation.