PRODUCTION OF HETEROLOGOUS EXTRACELLULAR POLYPEPTIDES IN YARROWIA LIPOLYTICA

PRODUCTION OF HETEROLOGOUS EXTRACELLULAR POLYPEPTIDES IN YARROWIA LIPOLYTICA

This invention relates to protein and/or polypeptide production, particularly improved production of extracellular heterologous polypeptides and proteins. In particular, the invention relates to compositions of cell populations capable of improved levels of extracellular secretion relative to contro...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: VAN ZYL, PETRUS JAKOBUS, RAMAGOMA, FARANANI, NTHANGENI, MULALO BETHUEL
Format: Patent
Sprache:eng ; fre
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:This invention relates to protein and/or polypeptide production, particularly improved production of extracellular heterologous polypeptides and proteins. In particular, the invention relates to compositions of cell populations capable of improved levels of extracellular secretion relative to control populations, kits containing such compositions, methods of producing heterologous proteins of interest and recombinant microorganisms capable of improved extracellular heterologous protein production. Cette invention concerne la production de protéines et/ou de polypeptides, en particulier la production améliorée de polypeptides et de protéines hétérologues extracellulaires. En particulier, l'invention concerne des compositions de populations cellulaires aptes aux niveaux améliorés de sécrétion extracellulaire par rapport à des populations témoins, des trousses contenant de telles compositions, des procédés de fabrication de protéines hétérologues d'intérêt et des microorganismes recombinants aptes à une production améliorée de protéines hétérologues extracellulaires.