1,3 OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS

The present invention provides 4-(3-Amino-phenyl)-5,6-dihydro-4H-[1,3]oxazin-2-ylamines of formula (I) having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present...

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Bibliographische Detailangaben
Hauptverfasser:	HILPERT, HANS, WOSTL, WOLFGANG
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides 4-(3-Amino-phenyl)-5,6-dihydro-4H-[1,3]oxazin-2-ylamines of formula (I) having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes. Cette invention concerne des 4-(3-amino-phényl)-5,6-dihydro- 4H-[1,3]oxazin-2-ylamines de formule (I) ayant une activité inhibitrice de BACE1 et/ou BACE2, leur fabrication, des compositions pharmaceutiques les contenant et leur utilisation à titre de principes thérapeutiquement actifs. Les principes actifs selon l'invention sont utiles dans le traitement thérapeutique et/ou prophylactique de, par exemple, la maladie d'Alzheimer et du diabète de type 2.