HYDROXYPHENYL PYRROLE COMPOUNDS CONTAINING AN HYDROXAMIC ACID AS HDAC INHIBITORS AND MEDICINAL APPLICATIONS THEREOF

The present invention refers to compounds derived from hydroxyphenyl 1H- pyrrole rings, which have the following formula (I): as well as to the procedure for their preparation, pharmaceutical compositions comprisingthe same and the use thereof for the treatment and/or prevention of a condition mediated by histone deacetylase such as cancer, hematological malignancies, autoimmune diseases, inflammatory diseases, diseases of the central nervous system (CNS) such as neurodegenerative diseases and psychiatric disorders, cardiovascular diseases, endocrine and metabolic disorders, by inhibiting histone deacetylases and the therapeutic use of biological processes related to the mentioned inhibition. La présente invention concerne des composés issus de cycles hydroxyphényl- 1H-pyrrole, de formule (I) suivante : , ainsi que leur procédé de fabrication, des compositions pharmaceutiques en contenant et leur utilisation en vue du traitement et/ou de la prévention d'une affection à médiation par l'histone désacétylase comme le cancer, les affections hématologiques malignes, les maladies auto-immunes, les maladies inflammatoires, les maladies du système nerveux central (SNC), telles que les maladies neurodégénératives et les affections psychiatriques, les maladies cardiovasculaires, les affections endocrines et métaboliques et ce, grâce à l'inhibition des histone désacétylases. L'invention concerne également l'utilisation thérapeutique de processus biologiques associés à ladite inhibition.