2-ANILINO NICOTINYL LINKED 2-AMINO BENZOTHIAZOLE CONJUGATES AND PROCESS FOR THE PREPARATION THEREOF

The present invention provides compounds of general formula A useful as potential anticancer agents against human cancer cell lines and apoptosis inducers. The present invention further provides a process for the preparation of 2-anilino nicotinyl linked 2-amino benzothiazole conjugates of general f...

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Bibliographische Detailangaben
Hauptverfasser:	SHASHI, BHUSHAN, KHAN, MOHAMMED, NASEER, AHMED, DAR, ABID, HAMID, MONDHE, DILIP, MANIKRAO, SAXENA, AJIT, JUMAR, SRIKANTH, YELLAMELLI, VALLI, VENKATA, KAMAL, AHMED, SEHAR, IRUM, CHASHOO, GOUSIA, ASHRAF, MOHAMMED, SINGH, SHASHANK, KUMAR, SHARMA, PARDUMAN, RAJ
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides compounds of general formula A useful as potential anticancer agents against human cancer cell lines and apoptosis inducers. The present invention further provides a process for the preparation of 2-anilino nicotinyl linked 2-amino benzothiazole conjugates of general formula (A), wherein R1 = H or CI; R2 = H, OCH3 or F; R3 = H, OCH3, F or CI; R4=H, OCH3 or F and X= OCH3, F or N02. L'invention concerne des composés de formule générale A pouvant servir d'agents anticancéreux potentiels agissant contre des lignées cellulaires de cancer humain et d'inducteurs d'apoptose. L'invention porte également sur un procédé de préparation de conjugés de 2-amino benzothiazole à liaison 2-anilino nicotinyl de formule générale (A), dans laquelle R1 = H ou CI; R2 = H, OCH3 ou F; R3 = H, OCH3, F ou CI; R4=H, OCH3 ou F et X= OCH3, F ou N02.