AN IMPROVED PROCESS FOR PREPARATION OF LEVONORGESTREL

The present invention provides an improved process for preparation of levonorgestrel (3) which comprises of hydrolysis of 13 ß-ethyl-3-methoxy-17a-ethynyl-gona-2,5(10)-dien-17ß- o1 (2) with an acid in aprotic solvent. The present invention also provides a novel process for purification of crude levo...

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Bibliographische Detailangaben
Hauptverfasser:	SINGH, GIRIJ, PAL, GODBOLE, HIMANSHU, MADHAV, ZADBUKE, SWAPNIL, AJIT, MEHARE, KISHOR, GULABRAO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY METALLURGY ORGANIC CHEMISTRY STEROIDS
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The present invention provides an improved process for preparation of levonorgestrel (3) which comprises of hydrolysis of 13 ß-ethyl-3-methoxy-17a-ethynyl-gona-2,5(10)-dien-17ß- o1 (2) with an acid in aprotic solvent. The present invention also provides a novel process for purification of crude levonorgestrel (3) by recrystallization from N,N-dimethyl formamide- water; methanol-water mixture. Cette invention concerne un procédé de préparation amélioré du lévonorgestrel(3) qui comprend l'hydrolyse d'un 13ß-éthyl-3-méthoxy- 17a-éthynyl-gona-2,5(10)-dién-17ß-o1 (2) avec un acide dans un solvant aprotique. Cette invention concerne également un nouveau procédé de purification du lévonorgestrel brut (3) par recristallisation à partir de N,N-diméthylformamide-eau ; mélange méthanol-eau.