PROCESS FOR MAKING TRISUBSTITUTED SILYLOXYETHYL TRIFLATES

PROCESS FOR MAKING TRISUBSTITUTED SILYLOXYETHYL TRIFLATES

An improved process for making, stabilizing and monitoring the compound of general formula (3) in which R1,R2,R3 are independently a straight or branched alkyl group of 1 to 10 carbon atoms and/or a phenyl group, is provided. The compounds of formula (3) are important intermediates in making the pha...

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Bibliographische Detailangaben
Hauptverfasser: BENES, MICHAL, JANOUSEK, VLADIMIR, PIS, JAROSLAV
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:An improved process for making, stabilizing and monitoring the compound of general formula (3) in which R1,R2,R3 are independently a straight or branched alkyl group of 1 to 10 carbon atoms and/or a phenyl group, is provided. The compounds of formula (3) are important intermediates in making the pharmaceutically active compound everolimus. L'invention porte sur un procédé perfectionné pour la fabrication, la stabilisation et le suivi du composé de formule générale (3) dans laquelle R1, R2 et R3 représentent chacun indépendamment un groupe alkyle droit ou ramifié ayant 1 à 10 atomes de carbone et/ou un groupe phényle. Les composés de formule (3) sont des intermédiaires importants dans la fabrication du composé pharmaceutiquement actif évérolimus.