POLY(ETHER IMINE) DENDRIMERS AND USES THEREOF

Non-viral poly(ether imine) (PETIM) dendrimers based gene delivery systems is disclosed herein, wherein the PETIM dendrimer constituted with tertiary amine branch points, n-propyl ether linkers and primary amines, with and without further functionalizations, at their peripheries, exhibits significan...

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Hauptverfasser:	YAMAJALA BHASKARA RAMA DURGA, RAJESH, JAYAMURUGAN, GOVINDASAMY, MADHUSUDANA, NARAYAN SHAMPUR, THANKAPPAN, PADINJAREMATTATHIL ULLAS, JAYARAMAN, NARAYANASWAMY, DESAI, ANITA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS BASED THEREON COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MANUFACTURE OR TREATMENT OF NANOSTRUCTURES MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NANOTECHNOLOGY ORGANIC MACROMOLECULAR COMPOUNDS PERFORMING OPERATIONS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES SPIRITS THEIR PREPARATION OR CHEMICAL WORKING-UP TRANSPORTING VINEGAR WINE
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Zusammenfassung:	Non-viral poly(ether imine) (PETIM) dendrimers based gene delivery systems is disclosed herein, wherein the PETIM dendrimer constituted with tertiary amine branch points, n-propyl ether linkers and primary amines, with and without further functionalizations, at their peripheries, exhibits significantly reduced toxicities, over a broad concentration range. The dendrimer complexes pDNA effectively, protects DNA from endosomal damages and delivers to cell nucleus. L'invention concerne des systèmes d'apport de gènes à base de dendrimères poly(éhterimine) (PETIM) non viraux. Le dendrimère PETIM constitué de points de ramification d'amine tertiaire, de lieurs n-propyle éther et d'amines primaires, avec ou sans autres fonctionnalisations, au niveau e leurs périphéries, présente des toxicités considérablement réduites sur une large plage de concentration. Ledit dendrimère complexe efficacement l'ADNp, protège l'ADN d'éventuels dommages endosomaux et le véhicule jusqu'au noyau cellulaire