SUBSTITUTED AMINO-TRIAZOLYL PDE10 INHIBITORS

The present invention is directed to substituted amino-triazolyl compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurologi...

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Hauptverfasser: STEEN, JUSTIN, T, BRACKEN, JACK, MCELROY, WILLIAM, T, HO, GINNY, SHIPPS, GERALD, W., JR, MCGAUGHEY, GEORGIA, DUDKIN, VADIM, SAUVAGNAT, BERENEGERE, DENG, YONGQI, COX, CHRISTOPHER, D, ZHU, LIANG, STEELE, THOMAS, G
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creator STEEN, JUSTIN, T
BRACKEN, JACK
MCELROY, WILLIAM, T
HO, GINNY
SHIPPS, GERALD, W., JR
MCGAUGHEY, GEORGIA
DUDKIN, VADIM
SAUVAGNAT, BERENEGERE
DENG, YONGQI
COX, CHRISTOPHER, D
ZHU, LIANG
STEELE, THOMAS, G
description The present invention is directed to substituted amino-triazolyl compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction. La présente invention concerne des composés amino-triazolyles substitués, utiles en tant qu'agents thérapeutiques dans le traitement de troubles du système nerveux central associés à la phosphodiestérase 10 (PDE10). La présente invention porte en outre sur l'utilisation de ces composés dans le traitement de troubles neurologiques et psychiatriques, tels que la schizophrénie, la psychose ou la maladie de Huntington, et de ceux associés à une hypofonction striatale ou à un dysfonctionnement des noyaux gris centraux.
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subjects AGRICULTURE
ANIMAL HUSBANDRY
BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
CHEMISTRY
FISHING
FORESTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HUNTING
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEST REPELLANTS OR ATTRACTANTS
PLANT GROWTH REGULATORS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF
TRAPPING
title SUBSTITUTED AMINO-TRIAZOLYL PDE10 INHIBITORS
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