SUBSTITUTED AMINO-TRIAZOLYL PDE10 INHIBITORS

The present invention is directed to substituted amino-triazolyl compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurologi...

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Bibliographische Detailangaben
Hauptverfasser:	STEEN, JUSTIN, T, BRACKEN, JACK, MCELROY, WILLIAM, T, HO, GINNY, SHIPPS, GERALD, W., JR, MCGAUGHEY, GEORGIA, DUDKIN, VADIM, SAUVAGNAT, BERENEGERE, DENG, YONGQI, COX, CHRISTOPHER, D, ZHU, LIANG, STEELE, THOMAS, G
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY FISHING FORESTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF TRAPPING
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Beschreibung
Zusammenfassung:	The present invention is directed to substituted amino-triazolyl compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction. La présente invention concerne des composés amino-triazolyles substitués, utiles en tant qu'agents thérapeutiques dans le traitement de troubles du système nerveux central associés à la phosphodiestérase 10 (PDE10). La présente invention porte en outre sur l'utilisation de ces composés dans le traitement de troubles neurologiques et psychiatriques, tels que la schizophrénie, la psychose ou la maladie de Huntington, et de ceux associés à une hypofonction striatale ou à un dysfonctionnement des noyaux gris centraux.