METHOD FOR ISOLATING CELLS AND A CELL POPULATION THEREOF

The present invention is directed to a method for the isolation of a cell population from a sample of human umbilical cord blood comprising steps of contacting said sample with an antibody binding to core-2 type O-glycan, with a sialyl Lewis x (s Lex) and Neu5Aca2- 3Galß1-3(Neu5Aca2-3Galß1-4Glc NAcß...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	NATUNEN, SUVI, KOTOVUORI, ANNIKA, PARTANEN, JUKKA, NATUNEN, JARI, VALMU, LEENA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention is directed to a method for the isolation of a cell population from a sample of human umbilical cord blood comprising steps of contacting said sample with an antibody binding to core-2 type O-glycan, with a sialyl Lewis x (s Lex) and Neu5Aca2- 3Galß1-3(Neu5Aca2-3Galß1-4Glc NAcß1-6)Gal NAca epitopes, such as CHO-131, and isolating the cells bound to said antibody. The invention also provides compositions comprising human cells isolated from umbilical cord blood. La présente invention concerne un procédé d'isolement d'une population de cellules à partir d'un échantillon de sang de cordon ombilical humain comprenant les étapes de mise dudit échantillon en contact avec un anticorps se liant à un O-glycane type core 2, avec un sialyl Lewis-X (s Lex) et des épitopes Neu5Aca2- 3Galß1-3(Neu5Aca2-3Galß1-4Glc NAcß1-6)Gal NAca, comme CHO-131, et l'isolement des cellules liées audit anticorps. L'invention concerne également des compositions comprenant des cellules humaines isolées à partir de sang de cordon ombilical.