CURCUMALACTONE DERIVATIVES WITH ANTITUMOR ACTIVITY AND PREPARATION PROCESS THEREOF

The invention relates to the field of medicine. Curcumalactone derivatives with antitumor activity and the process for their preparation are disclosed. The said curcumalactone derivatives and their oxidized derivatives have a spironolactone structure as in formula (I). The preparation process for th...

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Bibliographische Detailangaben
Hauptverfasser:	WU, YINGLIANG, JIA, XIAN, WAN, XIAOHUI, CHEN, YINAN, YIN, YUE, MA, XIAOSHUANG, YOU, SONG, XU, WEIZHUO, QIN, BIN
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to the field of medicine. Curcumalactone derivatives with antitumor activity and the process for their preparation are disclosed. The said curcumalactone derivatives and their oxidized derivatives have a spironolactone structure as in formula (I). The preparation process for these compounds are also provided, wherein biotransformation is used. The intermediates of the process as in formula (II) are disclosed. The present compounds have antitumor activity. L'invention concerne le domaine de la médicine. L'invention porte sur des dérivés de lactones de curcuma présentant une activité antitumorale et sur le procédé pour leur préparation. Lesdits dérivés de lactones de curcuma et leurs dérivés oxydés ont une structure de spironolactone telle que la structure (I) suivante. L'invention porte également sur le procédé de préparation pour ces composés, lequel utilise une biotransformation. L'invention porte également sur les intermédiaires du procédé représentés par la structure (II) suivante. Le