N- SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE - GATED SODIUM CHANNELS

N- SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE - GATED SODIUM CHANNELS

The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula 10 (I): (I) or a phar...

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Bibliographische Detailangaben
Hauptverfasser: BELL, ANDREW SIMON, PEREZ PACHECO, MANUEL, STORER, ROBERT IAN, BROWN, ALAN DANIEL, LEWTHWAITE, RUSSELL ANDREW, RAWSON, DAVID JAMES, SWAIN, NIGEL ALAN
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula 10 (I): (I) or a pharmaceutically acceptable salt thereof, wherein Z, R 1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain. L'invention concerne des dérivés de sulfonamide, leur utilisation en médecine, des compositions les contenant, des procédés pour les préparer et des intermédiaires utilisés dans ces procédés. Plus particulièrement, l'invention concerne de nouveaux inhibiteurs de sulfonamide Nav1.7 de formule (I): (I) ou un de leurs sels pharmaceutiquement acceptables, dans lesquels Z, R1, R2, R3, R4 et R5 sont tels que définis dans la description. Les inhibiteurs Nav 1.7 sont potentiellement utiles dans le traitement d'une large gamme de troubles, en particulier la douleur.