N-SULFONYLBENZAMIDE DERIVATIVES USEFUL AS VOLTAGE GATED SODIUM CHANNEL INHIBITORS

N-SULFONYLBENZAMIDE DERIVATIVES USEFUL AS VOLTAGE GATED SODIUM CHANNEL INHIBITORS

The invention relates to sulfonamide derivatives, to their use i n medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceut...

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Bibliographische Detailangaben
Hauptverfasser: SCIAMMETTA, NUNZIO, DE GROOT, MARCEL, JOHN, GAULIER, STEVEN, MATTHIEU, LEWTHWAITE, RUSSELL, ANDREW, MARSH, IAN, ROGER, PEREZ PACHECO, MANUEL, RAWSON, DAVID, JAMES, BROWN, ALAN, DANIEL, MILLAN, DAVID, SIMON, BELL, ANDREW, SIMON, STORER, ROBERT, IAN, SWAIN, NIGEL, ALAN
Format: Patent
Sprache:eng ; fre
Schlagworte:
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention relates to sulfonamide derivatives, to their use i n medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein Het1, X, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain. L'invention concerne des dérivés de sulfonamide, leur utilisation en médecine, des compositions les contenant, des procédés pour leur préparation et des intermédiaires utilisés dans ces procédés. Plus particulièrement, l'invention concerne de nouveaux inhibiteurs du canal Nav1.7 de type sulfonamide de formule (I): ou un sel pharmaceutiquement acceptable de ceux-ci, Het1, X, R1, R2, R3, R4 et R5 étant tels que définis dans la description. Les inhibiteurs du canal Nav 1.7 sont potentiellement utiles dans le traitement d'une large plage de troubles, en particulier la douleur.