NOVEL QUINOLINE ESTERS USEFUL FOR TREATING SKIN DISORDERS

Disclosed are quinoline esters of Formula (I):(I) which are useful as Liver X receptors (LXR) modulators. Pharmaceutical compositions containing quinoline esters of Formula (I) and the use of quinoline esters of Formula (I) in the safe treatment of various skin disorders are also disclosed. Methods...

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Bibliographische Detailangaben
Hauptverfasser:	SINGHAUS, ROBERT, NAGPAL, SUNIL, BERNOTAS, RONALD CHARLES, THOMPSON, CATHERINE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are quinoline esters of Formula (I):(I) which are useful as Liver X receptors (LXR) modulators. Pharmaceutical compositions containing quinoline esters of Formula (I) and the use of quinoline esters of Formula (I) in the safe treatment of various skin disorders are also disclosed. Methods for preparing and using quinoline esters are further described. L'invention concerne des esters de quinoléine de Formule (I):(I) qui sont utiles comme modulateurs des récepteurs X du foie (LXR). Elle concerne également des compositions pharmaceutiques contenant des esters de quinoléine de Formule (I) et l'utilisation d'esters de quinoléine de Formule (I) dans le traitement sûr de divers troubles cutanés. Elle concerne aussi des procédés de préparation et d'utilisation d'esters de quinoléine.