IMPROVED SYNTHESIS OF OPTICALLY PURE (S) - 3-CYANO-5-METHYL-HEXANOIC ACID ALKYL ESTER, AN INTERMEDIATE OF (S)- PREGABALIN

IMPROVED SYNTHESIS OF OPTICALLY PURE (S) - 3-CYANO-5-METHYL-HEXANOIC ACID ALKYL ESTER, AN INTERMEDIATE OF (S)- PREGABALIN

The present invention is directed towards synthesis of (S) - 3-cyano-5-methyl-hexanoic acid ethyl ester. A cost effective, eco-friendly process for preparation of enantiomerically pure (S)-3-cyano-5-methyl-hexanoic acid alkyl ester, intermediate of ?-amino acids, particularly (S)-pregabalin. Cette i...

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Bibliographische Detailangaben
Hauptverfasser: SINGH, GIRIJ, PAL, AGRAWAL, MANOJ, KUNJABIHARI, LATHI, PIYUSH, SURESH, ROY, BHAIRAB, NATH, PISE, VIJAY, SADASHIV
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention is directed towards synthesis of (S) - 3-cyano-5-methyl-hexanoic acid ethyl ester. A cost effective, eco-friendly process for preparation of enantiomerically pure (S)-3-cyano-5-methyl-hexanoic acid alkyl ester, intermediate of ?-amino acids, particularly (S)-pregabalin. Cette invention concerne la synthèse d'un ester éthylique de l'acide (S)-3-cyano-5-méthyl-hexanoïque. Cette invention se rapporte en outre à un procédé écologique et peu onéreux pour préparer un ester alkylique énantiomériquement pur de l'acide (S)-3-cyano-5-méthyl-hexanoïque, un intermédiaire d'?-amino-acides, en particulier de la (S)-prégabaline.