AZA-BICYCLIC AMINE N-OXIDE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGAND PRO-DRUGS

The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are prodrugs for ligands, agonists, and partial agonists for the nicotinic a7 receptor and may be useful for the treatment of various disorders...

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Bibliographische Detailangaben
Hauptverfasser:	OLSON, RICHARD E, HILL, MATTHEW D, IWUAGWU, CHRISTIANA I, MACOR, JOHN E, WANG, NENGHUI, ZUSI, F. CHRISTOPHER, MATE, ROBERT A, DENTON, REX, LENTZ, KIMBERLEY A, KING, DALTON, FANG, HAIQUAN, MCDONALD, IVAR M, COOK, JAMES H., II
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are prodrugs for ligands, agonists, and partial agonists for the nicotinic a7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders. L'invention concerne de manière générale des composés de formule I, y compris leurs sels, ainsi que des compositions et des procédés pour utiliser les composés. Les composés sont des promédicaments pour ligands, agonistes et agonistes partiels du récepteur nicotinique a7 et peuvent être utiles pour le traitement de divers troubles du système nerveux central, en particulier les troubles affectifs et neurodégénératifs.